Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.
| Published in | Science Discovery (Volume 7, Issue 2) |
| DOI | 10.11648/j.sd.20190702.14 |
| Page(s) | 78-81 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Di(2-ethylhexyl)phthalate, Autism Spectrum Disorder, Neurodevelopment
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APA Style
Boyang Hu, Yiting Song, Genan Liang, Yihuan Shao, Linling Qi, et al. (2019). Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Science Discovery, 7(2), 78-81. https://doi.org/10.11648/j.sd.20190702.14
ACS Style
Boyang Hu; Yiting Song; Genan Liang; Yihuan Shao; Linling Qi, et al. Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Sci. Discov. 2019, 7(2), 78-81. doi: 10.11648/j.sd.20190702.14
AMA Style
Boyang Hu, Yiting Song, Genan Liang, Yihuan Shao, Linling Qi, et al. Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP. Sci Discov. 2019;7(2):78-81. doi: 10.11648/j.sd.20190702.14
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Download@article{10.11648/j.sd.20190702.14,
author = {Boyang Hu and Yiting Song and Genan Liang and Yihuan Shao and Linling Qi and Xue Jiang and Yuemin Ding},
title = {Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP},
journal = {Science Discovery},
volume = {7},
number = {2},
pages = {78-81},
doi = {10.11648/j.sd.20190702.14},
url = {https://doi.org/10.11648/j.sd.20190702.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190702.14},
abstract = {Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.},
year = {2019}
}
TY - JOUR T1 - Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP AU - Boyang Hu AU - Yiting Song AU - Genan Liang AU - Yihuan Shao AU - Linling Qi AU - Xue Jiang AU - Yuemin Ding Y1 - 2019/05/23 PY - 2019 N1 - https://doi.org/10.11648/j.sd.20190702.14 DO - 10.11648/j.sd.20190702.14 T2 - Science Discovery JF - Science Discovery JO - Science Discovery SP - 78 EP - 81 PB - Science Publishing Group SN - 2331-0650 UR - https://doi.org/10.11648/j.sd.20190702.14 AB - Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings. VL - 7 IS - 2 ER -
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