Research Article
Kidney Transplantation: Our Experience in a Private Tertiary Center in Abuja
Issue:
Volume 14, Issue 2, June 2025
Pages:
12-19
Received:
5 April 2025
Accepted:
16 April 2025
Published:
26 May 2025
Abstract: Introduction: The success of kidney transplantation depend on the effectiveness in certain key factors including excellent donor compatibility, immunosuppression and good surgical techniques. Exciting prospects in kidney transplantation is envisaged especially with the launching of standards and guidelines for the establishment and coordinating organ/tissue transplantation services by the Federal Government of Nigeria in March, 2025. We have come a long way with our five year experience in kidney transplantation. The use of branded immunosuppressive agents, excellent HLA/DSA typing and compatibility as well as ‘top notch’ surgical and medical team of experts have exponentially achieved a favorable outcome. Challenges are not unusual but we are hopeful that the future is promising and will offer more advancement in ‘tips and tricks’ of successful lifelong kidney transplantation. We report our experience in kidney transplantation over a 5 year period in our center. Methodology: This is a retrospective cohort study involving patients who had kidney transplantation in our facility over a 5 year period from January 2020 to December 2024. A proforma was designed to obtain existing records from our data base. Data analysis was conducted using Python with its libraries including Pandas, Numpy and Matplotib. P value of less than 0.05 was considered statistically significant. Results: Descriptive Statistics showed that a total of 104 patients had kidney transplantation surgery over the prescribed period. 66.35% were males while 33.65% were females. The average age of recipients was 46.27 years with a range of 24 to 72 years while the average age donors was 26.12 years with a range of 18 to 50 years. The average length of hospital stay after donor nephrectomy was 4.14 days while the average length of hospital stay for recipients post-surgery was 9.50 days with a range of 7-12 days. The etiology of renal failure were mainly long-term hypertension in 38.46%, diabetic mellitus in 29.81%, combination of both comorbid condition in 28.85%, autoimmune disease in 1.92% and genetic factor in 0.96%. Prognosis six months post-surgery was good in 82.69% and only 17.31% had unfavorable outcome. No donor mortality was observed. Conclusion: We have come a long way with our 5 years experience in management of end stage kidney disease in tropical Africa with excellent outcome. Though challenges are inevitable, the future still hold a promising exiting prospects as we envisage progressive experience and welcome new innovations including the use of minimal access techniques to achieve improved results.
Abstract: Introduction: The success of kidney transplantation depend on the effectiveness in certain key factors including excellent donor compatibility, immunosuppression and good surgical techniques. Exciting prospects in kidney transplantation is envisaged especially with the launching of standards and guidelines for the establishment and coordinating org...
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Research Article
Impact of Benzene Exposure on Hematological Parameters in Workers: A Comparative Cross-sectional Study with Healthy Non-Exposed Controls in Sudan
Issue:
Volume 14, Issue 2, June 2025
Pages:
20-26
Received:
20 April 2025
Accepted:
8 May 2025
Published:
30 June 2025
DOI:
10.11648/j.sjcm.20251402.12
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Abstract: Benzene toxicity can lead to a range of serious health impairments, including various forms of anemia and several types of cancer, such as multiple myeloma, lymphoma, and leukemia. It is crucial to minimize exposure to benzene in industrial and environmental settings to protect public health and prevent these potentially life-threatening conditions. To investigate the potential impact of benzene exposure on the hematological profile of workers and to compare the results with those of a healthy, non-exposed population. A comparative cross-sectional study was conducted from July to November 2022 with Benzene workers at the Kosti benzene stations in Sudan were divided into two groups for a study: an exposure group consisting of eighty-seven individuals who were exposed to benzene, and an unexposed group of eighty-seven individuals who had no exposure. Blood samples were collected from all participants in Ethylene Diamine Tetra Acetic Acid (EDTA) tubes for Complete Blood Count (CBC) analysis. The results indicated that the mean values for Red Blood Cells (RBCs) count were significantly higher in the exposure group compared to the control group. Similarly, the lymphocyte count showed a significant increase in the exposure group versus the control group (P<0.001). Additionally, the Mean Cell Hemoglobin Concentration (MCHC) was also significantly elevated in the exposed individuals compared to the healthy participants (P<0.001). Conversely, the mean values for Mean Cell Volume (MCV) were significantly lower in the exposure group compared to the control group. Hemoglobin (Hb) levels were also significantly reduced in the exposed group versus the control group (P<0.001). The packed cell volume (PCV) was lower in the exposure group compared to the control (P<0.001). Other hematological significant decreases were observed in Mean Cell Hemoglobin (MCH), Neutrophil count, Monocyte count and Platelet (PLTs) count (P < 0.001). No significant differences were found in the mean values of Total White Blood Cells (TWBCs) count and Eosinophil count between the exposed and non-exposed groups. This analytical comparative study highlights the substantial influence of benzene exposure on the hematological parameters of Sudanese workers, indicating notable disparities in hematological variables, thus emphasizing the need for occupational exposure monitoring and protective strategies for benzine workers.
Abstract: Benzene toxicity can lead to a range of serious health impairments, including various forms of anemia and several types of cancer, such as multiple myeloma, lymphoma, and leukemia. It is crucial to minimize exposure to benzene in industrial and environmental settings to protect public health and prevent these potentially life-threatening conditions...
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,
Agrawal Rajesh Kumar
